001package org.biopax.paxtools.model.level3;
002
003
004/**
005 * Defines the nature of the control relationship between the controller and the controlled entities.
006*/
007public enum ControlType
008{
009        /**
010         * General activation. Compounds that activate the specified enzyme activity by an unknown mechanism. The
011         * mechanism is defined as unknown, because either the mechanism has yet to be elucidated in the experimental
012         * literature, or the paper(s) curated thus far do not define the mechanism, and a full literature search has
013         * yet to be performed.
014         */
015        ACTIVATION,
016        /**
017         * General inhibition. Compounds that inhibit the specified enzyme activity by an unknown mechanism. The
018         * mechanism is defined as unknown, because either the mechanism has yet to be elucidated in the experimental
019         * literature, or the paper(s) curated thus far do not define the mechanism, and a full literature search has
020         * yet to be performed.
021         */
022        INHIBITION,
023
024        /**
025         * @deprecated LEVEL 1 workaround
026         */
027        ACTIVATION_UNKMECH,
028        /**
029         * @deprecated LEVEL 1 workaround
030         */
031        INHIBITION_UNKMECH,
032        /**
033         * Allosteric inhibitors decrease the specified enzyme activity by binding reversibly to the enzyme and
034         * inducing a conformational change that decreases the affinity of the enzyme to its substrates without
035         * affecting its VMAX. Allosteric inhibitors can be competitive or noncompetitive inhibitors, therefore,
036         * those inhibition categories can be used in conjunction with this category.
037         */
038        INHIBITION_ALLOSTERIC,
039        /**
040         * Competitive inhibitors are compounds that competitively inhibit the specified enzyme activity by binding
041         * reversibly to the enzyme and preventing the substrate from binding. Binding of the inhibitor and substrate
042         * are mutually exclusive because it is assumed that the inhibitor and substrate can both bind only to the free
043         * enzyme. A competitive inhibitor can either bind to the active site of the enzyme,
044         * directly excluding the substrate from binding there, or it can bind to another site on the enzyme,
045         * altering the conformation of the enzyme such that the substrate can not bind to the active site.
046         */
047        INHIBITION_COMPETITIVE,
048        /**
049         * Irreversible inhibitors are compounds that irreversibly inhibit the specified enzyme activity by binding to
050         * the enzyme and dissociating so slowly that it is considered irreversible. For example, alkylating agents,
051         * such as iodoacetamide, irreversibly inhibit the catalytic activity of some enzymes by modifying cysteine
052         * side chains.
053         */
054        INHIBITION_IRREVERSIBLE,
055        /**
056         * Noncompetitive inhibitors are compounds that noncompetitively inhibit the specified enzyme by binding
057         * reversibly to both the free enzyme and to the enzyme-substrate complex. The inhibitor and substrate may be
058         * bound to the enzyme simultaneously and do not exclude each other. However, only the enzyme-substrate complex
059         * (not the enzyme-substrate-inhibitor complex) is catalytically active.
060         */
061        INHIBITION_NONCOMPETITIVE,
062        /**
063         * Compounds that inhibit the specified enzyme activity by a mechanism that has been characterized,
064         * but that cannot be clearly classified as irreversible, competitive, noncompetitive, uncompetitive,
065         * or allosteric.
066         */
067        INHIBITION_OTHER,
068        /**
069         * Uncompetitive inhibitors are compounds that uncompetitively inhibit the specified enzyme activity by binding
070         * reversibly to the enzyme-substrate complex but not to the enzyme alone.
071         */
072        INHIBITION_UNCOMPETITIVE,
073        /**
074         * Nonallosteric activators increase the specified enzyme activity by means other than allosteric.
075         */
076        ACTIVATION_NONALLOSTERIC,
077        /**
078         * Allosteric activators increase the specified enzyme activity by binding reversibly to the enzyme and
079         * inducing a conformational change that increases the affinity of the enzyme to its substrates without
080         * affecting its VMAX.
081         */
082        ACTIVATION_ALLOSTERIC
083}